Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Tezzeret's Gambit

({U/P} can be paid with either {U} or 2 life.)
Draw two cards, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Kaya's Guile

Choose two —
• Each opponent sacrifices a creature.
• Exile all opponents' graveyards.
• Create a 1/1 white and black Spirit creature token with flying.
• You gain 4 life.
Entwine {3} (Choose all if you pay the entwine cost.)

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Stromgald Cabal

{T}, Pay 1 life: Counter target white spell.

Trespassing Souleater

{U/P}: Trespassing Souleater can't be blocked this turn. ({U/P} can be paid with either {U} or 2 life.)

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Marrow Shards

({W/P} can be paid with either {W} or 2 life.)
Marrow Shards deals 1 damage to each attacking creature.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Phyrexian Metamorph

({U/P} can be paid with either {U} or 2 life.)
You may have Phyrexian Metamorph enter the battlefield as a copy of any artifact or creature on the battlefield, except it's an artifact in addition to its other types.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Greed

Souldrinker

Pay 3 life: Put a +1/+1 counter on Souldrinker.

Blinding Souleater

{W/P}, {T}: Tap target creature. ({W/P} can be paid with either {W} or 2 life.)

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Dusk Mangler

As an additional cost to cast this spell, sacrifice a creature, discard a card, or pay 4 life.
When Dusk Mangler enters the battlefield, each opponent sacrifices a creature, discards a card, and loses 4 life.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Ambition's Cost

You draw three cards and you lose 3 life.

Vault Skirge

({B/P} can be paid with either {B} or 2 life.)
Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Mental Misstep

({U/P} can be paid with either {U} or 2 life.)
Counter target spell with mana value 1.

Deepwood Ghoul

Nyx-Fleece Ram

At the beginning of your upkeep, you gain 1 life.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Porcelain Legionnaire

({W/P} can be paid with either {W} or 2 life.)
First strike

Spellskite

{U/P}: Change a target of target spell or ability to Spellskite. ({U/P} can be paid with either {U} or 2 life.)

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on Bloodtracker.
When Bloodtracker leaves the battlefield, draw a card for each +1/+1 counter on it.

Cathedral Membrane

({W/P} can be paid with either {W} or 2 life.)
Defender
When Cathedral Membrane dies during combat, it deals 6 damage to each creature it blocked this combat.

Surgical Extraction

({B/P} can be paid with either {B} or 2 life.)
Choose target card in a graveyard other than a basic land card. Search its owner's graveyard, hand, and library for any number of cards with the same name as that card and exile them. Then that player shuffles.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Apostle's Blessing

({W/P} can be paid with either {W} or 2 life.)
Target artifact or creature you control gains protection from artifacts or from the color of your choice until end of turn.

Norn's Annex

({W/P} can be paid with either {W} or 2 life.)
Creatures can't attack you or planeswalkers you control unless their controller pays {W/P} for each of those creatures.

Sangrophage

At the beginning of your upkeep, tap Sangrophage unless you pay 2 life.

Pith Driller

({B/P} can be paid with either {B} or 2 life.)
When Pith Driller enters the battlefield, put a -1/-1 counter on target creature.

Oloro, Ageless Ascetic

At the beginning of your upkeep, you gain 2 life.
Whenever you gain life, you may pay {1}. If you do, draw a card and each opponent loses 1 life.
At the beginning of your upkeep, if Oloro, Ageless Ascetic is in the command zone, you gain 2 life.

Ashes to Ashes

Exile two target nonartifact creatures. Ashes to Ashes deals 5 damage to you.

Spined Thopter

({U/P} can be paid with either {U} or 2 life.)
Flying

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.