Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Eye of Vecna

When Eye of Vecna enters the battlefield, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Archaeomancer's Map

When Archaeomancer's Map enters the battlefield, search your library for up to two basic Plains cards, reveal them, put them into your hand, then shuffle.
Whenever a land enters the battlefield under an opponent's control, if that player controls more lands than you, you may put a land card from your hand onto the battlefield.

Damnable Pact

Target player draws X cards and loses X life.

Isolated Chapel

Isolated Chapel enters the battlefield tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Land Tax

At the beginning of your upkeep, if an opponent controls more lands than you, you may search your library for up to three basic land cards, reveal them, put them into your hand, then shuffle.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Mortify

Eternity Vessel

Eternity Vessel enters the battlefield with X charge counters on it, where X is your life total.
Landfall — Whenever a land enters the battlefield under your control, you may have your life total become the number of charge counters on Eternity Vessel.

Wrath of God

Destroy all creatures. They can't be regenerated.

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Courageous Resolve

Up to one target creature you control gains protection from each of your opponents until end of turn. Draw a card. (It can't be blocked, targeted, dealt damage, enchanted, or equipped by anything controlled by those players.)
Fateful hour — If you have 5 or less life, you can't lose life this turn, you can't lose the game this turn, and your opponents can't win the game this turn.

Knight of the White Orchid

First strike
When Knight of the White Orchid enters the battlefield, if an opponent controls more lands than you, you may search your library for a Plains card, put it onto the battlefield, then shuffle.

Despark

Exile target permanent with mana value 4 or greater.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Resolute Archangel

Flying
When Resolute Archangel enters the battlefield, if your life total is less than your starting life total, it becomes equal to your starting life total.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Razor Barrier

Target permanent you control gains protection from artifacts or from the color of your choice until end of turn.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Swamp

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Kaervek's Spite

As an additional cost to cast this spell, sacrifice all permanents you control and discard your hand.
Target player loses 5 life.

Faith's Shield

Target permanent you control gains protection from the color of your choice until end of turn.
Fateful hour — If you have 5 or less life, instead you and each permanent you control gain protection from the color of your choice until end of turn.

Planar Collapse

At the beginning of your upkeep, if there are four or more creatures on the battlefield, sacrifice Planar Collapse and destroy all creatures. They can't be regenerated.

Orzhov Signet

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Greed

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Burnished Hart

{3}, Sacrifice Burnished Hart: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Renounce

Sacrifice any number of permanents. You gain 2 life for each permanent sacrificed this way.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Pristine Talisman

Ancient Craving

You draw three cards and you lose 3 life.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Reliquary Tower

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia, Dark Angel to its owner's hand.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Charcoal Diamond

Charcoal Diamond enters the battlefield tapped.
{T}: Add {B}.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Plains

Marble Diamond

Marble Diamond enters the battlefield tapped.
{T}: Add {W}.

Netherborn Phalanx

When Netherborn Phalanx enters the battlefield, each opponent loses 1 life for each creature they control.
Transmute {1}{B}{B} ({1}{B}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then shuffle. Transmute only as a sorcery.)

Dark Ritual

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Sign in Blood

Target player draws two cards and loses 2 life.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Emergence Zone

{T}: Add {C}.
{1}, {T}, Sacrifice Emergence Zone: You may cast spells this turn as though they had flash.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Temple of the False God

{T}: Add {C}{C}. Activate only if you control five or more lands.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Night's Whisper

Angelic Enforcer

Flying
You have hexproof.
Angelic Enforcer's power and toughness are each equal to your life total.
Whenever Angelic Enforcer attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform Enduring Angel and your life total becomes 3. Then if Enduring Angel didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Beseech the Queen

({2/B} can be paid with any two mana or with {B}. This card's mana value is 6.)
Search your library for a card with mana value less than or equal to the number of lands you control, reveal it, put it into your hand, then shuffle.

Vedalken Orrery

You may cast spells as though they had flash.

Death Grasp

Death Grasp deals X damage to any target. You gain X life.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters the battlefield tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Phyrexian Processor

As Phyrexian Processor enters the battlefield, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered the battlefield.

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on Bloodtracker.
When Bloodtracker leaves the battlefield, draw a card for each +1/+1 counter on it.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

One with Nothing

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Sickening Dreams

As an additional cost to cast this spell, discard X cards.
Sickening Dreams deals X damage to each creature and each player.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Vindicate

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.