Invoke Despair

Target opponent sacrifices a creature. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Whispers of Emrakul

Target opponent discards a card at random.
Delirium — If there are four or more card types among cards in your graveyard, that player discards two cards at random instead.

Soul-Guide Lantern

When Soul-Guide Lantern enters the battlefield, exile target card from a graveyard.
{T}, Sacrifice Soul-Guide Lantern: Exile each opponent's graveyard.
{1}, {T}, Sacrifice Soul-Guide Lantern: Draw a card.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Flunk

Target creature gets -X/-X until end of turn, where X is 7 minus the number of cards in that creature's controller's hand.

Liliana's Defeat

Destroy target black creature or black planeswalker. If that permanent was a Liliana planeswalker, her controller loses 3 life.

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Extinction Event

Choose odd or even. Exile each creature with mana value of the chosen quality. (Zero is even.)

Pithing Needle

As Pithing Needle enters the battlefield, choose a card name.
Activated abilities of sources with the chosen name can't be activated unless they're mana abilities.

The Filigree Sylex

{T}: Put an oil counter on The Filigree Sylex.
{T}, Sacrifice The Filigree Sylex: Destroy each nonland permanent with mana value equal to the number of oil counters on The Filigree Sylex.
{T}, Remove ten oil counters from among permanents you control and sacrifice The Filigree Sylex: It deals 10 damage to any target.

Liliana, Waker of the Dead

+1: Each player discards a card. Each opponent who can't loses 3 life.
−3: Target creature gets -X/-X until end of turn, where X is the number of cards in your graveyard.
−7: You get an emblem with "At the beginning of combat on your turn, put target creature card from a graveyard onto the battlefield under your control. It gains haste."

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature.
• Each opponent sacrifices a creature token.
• Each opponent sacrifices a planeswalker.

Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Kitesail Freebooter

Flying
When Kitesail Freebooter enters the battlefield, target opponent reveals their hand. You choose a noncreature, nonland card from it. Exile that card until Kitesail Freebooter leaves the battlefield.

Castle Locthwain

Castle Locthwain enters the battlefield tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Liliana of the Veil

+1: Each player discards a card.
−2: Target player sacrifices a creature.
−6: Separate all permanents target player controls into two piles. That player sacrifices all permanents in the pile of their choice.

Power Word Kill

Destroy target non-Angel, non-Demon, non-Devil, non-Dragon creature.

Go Blank

Target player discards two cards. Then exile that player's graveyard.

Mirrex

{T}: Add {C}.
{T}: Add one mana of any color. Activate only if Mirrex entered the battlefield this turn.
{3}, {T}: Create a 1/1 colorless Phyrexian Mite artifact creature token with toxic 1 and "This creature can't block." (Players dealt combat damage by it also get a poison counter.)

Go for the Throat

Hive of the Eye Tyrant

If you control two or more other lands, Hive of the Eye Tyrant enters the battlefield tapped.
{T}: Add {B}.
{3}{B}: Until end of turn, Hive of the Eye Tyrant becomes a 3/3 black Beholder creature with menace and "Whenever this creature attacks, exile target card from defending player's graveyard." It's still a land.

Swamp

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Drown in Ichor

Target creature gets -4/-4 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Fatal Push

Destroy target creature if it has mana value 2 or less.
Revolt — Destroy that creature if it has mana value 4 or less instead if a permanent you controlled left the battlefield this turn.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Bloodchief's Thirst

Kicker {2}{B} (You may pay an additional {2}{B} as you cast this spell.)
Destroy target creature or planeswalker with mana value 2 or less. If this spell was kicked, instead destroy target creature or planeswalker.