Mass Calcify

Citywide Bust

Destroy all creatures with toughness 4 or greater.

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Day of Judgment

Mind's Eye

Whenever an opponent draws a card, you may pay {1}. If you do, draw a card.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Nevinyrral's Disk

Nevinyrral's Disk enters the battlefield tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Urza's Sylex

{2}{W}{W}, {T}, Exile Urza's Sylex: Each player chooses six lands they control. Destroy all other permanents. Activate only as a sorcery.
When Urza's Sylex is put into exile from the battlefield, you may pay {2}. If you do, search your library for a planeswalker card, reveal it, put it into your hand, then shuffle.

Sunscour

You may exile two white cards from your hand rather than pay this spell's mana cost.
Destroy all creatures.

Sword of the Animist

Equipped creature gets +1/+1.
Whenever equipped creature attacks, you may search your library for a basic land card, put it onto the battlefield tapped, then shuffle.
Equip {2}

Caged Sun

As Caged Sun enters the battlefield, choose a color.
Creatures you control of the chosen color get +1/+1.
Whenever a land's ability causes you to add one or more mana of the chosen color, add one additional mana of that color.

Sublime Exhalation

Undaunted (This spell costs {1} less to cast for each opponent.)
Destroy all creatures.

Gilded Lotus

Homeward Path

{T}: Add {C}.
{T}: Each player gains control of all creatures they own.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Planar Cleansing

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Serenity

At the beginning of your upkeep, destroy all artifacts and enchantments. They can't be regenerated.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Minas Tirith

Minas Tirith enters the battlefield tapped unless you control a legendary creature.
{T}: Add {W}.
{1}{W}, {T}: Draw a card. Activate only if you attacked with two or more creatures this turn.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Oblivion Stone

{4}, {T}: Put a fate counter on target permanent.
{5}, {T}, Sacrifice Oblivion Stone: Destroy each nonland permanent without a fate counter on it, then remove all fate counters from all permanents.

Purify

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Whispersilk Cloak

Equipped creature can't be blocked and has shroud. (It can't be the target of spells or abilities.)
Equip {2}

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Expel the Interlopers

Choose a number between 0 and 10. Destroy all creatures with power greater than or equal to the chosen number.

Fall of the Thran

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Destroy all lands.
II, III — Each player returns two land cards from their graveyard to the battlefield.

Sol Ring

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2. (Look at the top two cards of your library, then put any number of them on the bottom of your library and the rest on top in any order.)

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Commander's Plate

Equipped creature gets +3/+3 and has protection from each color that's not in your commander's color identity.
Equip commander {3}
Equip {5}

Magus of the Disk

Magus of the Disk enters the battlefield tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Eiganjo, Seat of the Empire

{T}: Add {W}.
Channel — {2}{W}, Discard Eiganjo, Seat of the Empire: It deals 4 damage to target attacking or blocking creature. This ability costs {1} less to activate for each legendary creature you control.

Pearl Medallion

White spells you cast cost {1} less to cast.

Serra Ascendant

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
As long as you have 30 or more life, Serra Ascendant gets +5/+5 and has flying.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Worldslayer

Whenever equipped creature deals combat damage to a player, destroy all permanents other than Worldslayer.
Equip {5} ({5}: Attach to target creature you control. Equip only as a sorcery.)

Shadowspear

Equipped creature gets +1/+1 and has trample and lifelink.
{1}: Permanents your opponents control lose hexproof and indestructible until end of turn.
Equip {2}

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Ondu Skyruins

Ondu Skyruins enters the battlefield tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

White Sun's Twilight

You gain X life. Create X 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This creature can't block." If X is 5 or more, destroy all other creatures. (Players dealt combat damage by a creature with toxic 1 also get a poison counter.)

Soulscour

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Plains

Ravnica at War

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Elspeth, Sun's Champion

+1: Create three 1/1 white Soldier creature tokens.
−3: Destroy all creatures with power 4 or greater.
−7: You get an emblem with "Creatures you control get +2/+2 and have flying."

Steelshaper's Gift

Search your library for an Equipment card, reveal that card, put it into your hand, then shuffle.

Rest in Peace

When Rest in Peace enters the battlefield, exile all graveyards.
If a card or token would be put into a graveyard from anywhere, exile it instead.

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Armageddon

Devastating Mastery

You may pay {2}{W}{W} rather than pay this spell's mana cost.
If the {2}{W}{W} cost was paid, an opponent chooses up to two nonland permanents they control and returns them to their owner's hand.
Destroy all nonland permanents.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Scourglass

{T}, Sacrifice Scourglass: Destroy all permanents except for artifacts and lands. Activate only during your upkeep.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Open the Armory

Search your library for an Aura or Equipment card, reveal it, put it into your hand, then shuffle.