Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Mishra's Bauble

{T}, Sacrifice Mishra's Bauble: Look at the top card of target player's library. Draw a card at the beginning of the next turn's upkeep.

Geralf's Messenger

Geralf's Messenger enters the battlefield tapped.
When Geralf's Messenger enters the battlefield, target opponent loses 2 life.
Undying (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Syphon Life

Target player loses 2 life and you gain 2 life.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Dash Hopes

When you cast this spell, any player may pay 5 life. If a player does, counter Dash Hopes.
Counter target spell.

Cut Down

Destroy target creature with total power and toughness 5 or less.

Bump in the Night

Target opponent loses 3 life.
Flashback {5}{R} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Throne of Geth

{T}, Sacrifice an artifact: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Swamp

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Sign in Blood

Target player draws two cards and loses 2 life.

Sinister Possession

Enchant creature
Whenever enchanted creature attacks or blocks, its controller loses 2 life.