Confront the Unknown

Investigate, then target creature gets +1/+1 until end of turn for each Clue you control. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Hard Evidence

Create a 0/3 blue Crab creature token.
Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

They Went This Way

Search your library for a basic land card, put it onto the battlefield tapped, then shuffle. Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Case of the Filched Falcon

When this Case enters the battlefield, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
To solve — You control three or more artifacts. (If unsolved, solve at the beginning of your end step.)
Solved — {2}{U}, Sacrifice this Case: Put four +1/+1 counters on target noncreature artifact. It becomes a 0/0 Bird creature with flying in addition to its other types.

Lonis, Genetics Expert

Evolve (Whenever a creature enters the battlefield under your control, if that creature has greater power or toughness than this creature, put a +1/+1 counter on this creature.)
Whenever one or more +1/+1 counters are put on Lonis, investigate that many times.
Whenever you sacrifice a Clue, put a +1/+1 counter on another target creature you control.

Fleeting Memories

When Fleeting Memories enters the battlefield, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you sacrifice a Clue, target player mills three cards.

Curious Inquiry

Enchant creature
Enchanted creature gets +1/+1 and has "Whenever this creature deals combat damage to a player, investigate." (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Fae Offering

At the beginning of each end step, if you've cast both a creature spell and a noncreature spell this turn, create a Clue token, a Food token, and a Treasure token.

Briarbridge Tracker

Vigilance
When Briarbridge Tracker enters the battlefield, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
As long as you control a token, Briarbridge Tracker gets +2/+0.

In Too Deep

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Enchant creature, planeswalker, or Clue
Enchanted permanent is a colorless Clue artifact with "{2}, Sacrifice this artifact: Draw a card" and loses all other abilities. (It's no longer a creature or planeswalker.)

Briarbridge Patrol

Whenever Briarbridge Patrol deals damage to one or more creatures, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
At the beginning of each end step, if you sacrificed three or more Clues this turn, you may put a creature card from your hand onto the battlefield.

Sharp-Eyed Rookie

Vigilance
Whenever a creature enters the battlefield under your control, if its power is greater than Sharp-Eyed Rookie's power or its toughness is greater than Sharp-Eyed Rookie's toughness, put a +1/+1 counter on Sharp-Eyed Rookie and investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Hold for Questioning

Enchant creature or planeswalker
When Hold for Questioning enters the battlefield, tap enchanted permanent and investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Enchanted permanent doesn't untap during its controller's untap step and its activated abilities can't be activated.

Tangletrove Kelp

Ward {2}
At the beginning of each combat, other Clues you control become 6/6 Plant creatures in addition to their other types until end of turn.
{2}, Sacrifice Tangletrove Kelp: Draw a card.

Deduce

Draw a card. Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Tireless Tracker

Landfall — Whenever a land enters the battlefield under your control, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you sacrifice a Clue, put a +1/+1 counter on Tireless Tracker.

Evidence Examiner

At the beginning of combat on your turn, you may collect evidence 4. (Exile cards with total mana value 4 or greater from your graveyard.)
Whenever you collect evidence, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Lonis, Cryptozoologist

Whenever another nontoken creature enters the battlefield under your control, investigate.
{T}, Sacrifice X Clues: Target opponent reveals the top X cards of their library. You may put a nonland permanent card with mana value X or less from among them onto the battlefield under your control. That player puts the rest on the bottom of their library in a random order.

Five Hundred Year Diary

Five Hundred Year Diary enters the battlefield tapped.
{T}: Add {U} for each Clue you control.
{2}, Sacrifice Five Hundred Year Diary: Draw a card.

Trail of Evidence

Whenever you cast an instant or sorcery spell, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

The Third Doctor

Trample
The Third Doctor gets +1/+1 for each noncreature token you control.
When The Third Doctor enters the battlefield, create your choice of a Clue token, a Food token, or a Treasure token.