Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Howling Golem

Whenever Howling Golem attacks or blocks, each player draws a card.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Sign in Blood

Target player draws two cards and loses 2 life.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Dark Ritual

Damnation

Destroy all creatures. They can't be regenerated.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Clockwork Fox

When Clockwork Fox leaves the battlefield, you draw two cards and each opponent draws a card.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Nuclear Fallout

Each creature gets twice -X/-X until end of turn. Each player gets X rad counters.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Damnable Pact

Target player draws X cards and loses X life.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Vein Ripper

Flying
Ward—Sacrifice a creature.
Whenever a creature dies, target opponent loses 2 life and you gain 2 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Invoke Despair

Target opponent sacrifices a creature. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Marauding Blight-Priest

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Elder Brain

Menace
Whenever Elder Brain attacks a player, exile all cards from that player's hand, then they draw that many cards. You may play lands and cast spells from among the exiled cards for as long as they remain exiled. If you cast a spell this way, you may spend mana as though it were mana of any color to cast it.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Wretched Confluence

Choose three. You may choose the same mode more than once.
• Target player draws a card and loses 1 life.
• Target creature gets -2/-2 until end of turn.
• Return target creature card from your graveyard to your hand.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.